Can 22" rims go on a 2010 mustang?
Those wheels probably weigh at least 75lbs a piece, so your acceleration will suffer badly, your gas mileage will suffer badly, your ride will suffer, and you can probably forget about any type of springs with wheels that big.
Also, any mustang that rolls 22's looks retarded and unbelievably ghetto.
So essentially if your a black drug dealer just looking to roll up to your 7th baby mamas house, 22's should be fine.
If your a decent human being, get some lightweight 20's and sack up.