Actually a lesser offset pushes the wheel/tire further outboard, not inboard. Also, it's more the design of the wheel spokes that clears or don't clear big brake calipers. But I don't think we are talking big brakes.
The 22mm vs. say a 35mm offset only amounts to the wheel assembly moving outbound by 1/2". Chances are you'd just be looking at the wheel possibly sticking out from the fender a bit.
Take a look at this site to get a better idea of what happens when sizes change. Typically it's used to check for clearance compared to an existing setup.
Rim & Tire Size Calculator. Custom Offsets - Wheel-Size.com
Moving the wheel outboard by a 1/2" by way of the offset would have a similar load effect on the wheel bearings as would putting in 1/2" spacers. Some don't recommend that much for the front wheels.
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