I assume you're talking about a coyote 5.0.
The coyotes are 8 bolt cranks, and 4.6's were both 6 and 8 bolt. I do not believe they would interchange, and same for the heads an intake. The 4.6's were internally balanced. You could swap some 5.4 stuff and 4v 4.6 stuff between the 4.6 blocks however.
2000 Mustang GT-Former giggle gas addict
1990 Mustang GT w/ Vortech V3
***resident gun idiot***