The block can handle it, it will need to be fully forged with the right combo, right fuel system and the entire driveline/chassis of the car will need to be gone through to handle the power or you'll just blow up whatever is behind a 2V at 15-20 psi. Although PSI really means nothing if you don't know the rest of the combo. Something making 12 psi can be putting way more power down than something else at 15 depending on what is done.
2000 Mustang GT Steeda #0048
Just because I give you advice, doesn't mean I know more than you. Its just means I've done more stupid ****.