Anything is possible with enough money, time, and skill.
I would think the new cammer engines would be a really tight fit. I know it's quite tight in my project car--'73 Pinto with a 351W, and that is with smaller pushrod heads. IIRC, basically the same platform. I would think fender wells will need to go & hood might (probably) would need to be a cowl one. I would also anticipate cutting out the engine mounts & replacing them if they are for a Windsor block--I'd be surprised if the modulars have the same mounts.