I ran across this video by Steve Dinan about tuning the ECU.
I keep up with Dinan Performance as they were one of the only places I could run my 408 motor on an engine dyno and was fortunate to have Dusty Renteria of the Renteria Brothers ProMod Valiant...high 5.9's in the 1/4 mile...do the set up and tuning of my old motor. Anyway Steve Dinan started moding ECU's back in the 80's and although he talks a lot about BMW's he has some interesting comments about tuning...
Renteria Brothers ProMod Valiant
Renteria Brothers - Ask.com YouTube Search
Steve Dinan on ECU Tuning
Diving Into The Technical Advantages Of Modern ECU Tuning