Safe is just a matter of opinion, and how you drive it. I know these cars go through a "break in" procedure from the factory, but i still treat every new car like a built motor.
Oil change at 500, and oil change at 1000 to flush all the shavings and things out as the motor is breaking in. It can be cheap oil, its literally just for the sake of removing debris as the parts start wearing to each other. No WOT under 500 miles, and i try to keep the engine under 3000-3500 or so. from 500-1000 i'll gradually start leaning into the throttle and going higher in the rev range with LOTS of engine braking (engine braking really helps set the piston rings). After the 1000 miles, i put my good oil in and drive it like i stole it.
Point being: You can put the mods and tune on right now, and it makes no difference, its basically how you drive it that counts. Some people hop right on a new motor and go for broke, some like to break them in a bit...
My method is probably overkill, but i am kind of OCD about my cars... i know i abuse the hell out of them, so i try to do them every favor i can along the way.