On my last 5.0....(an '88) built, as a theme, with junkyard parts, I had nitrous
first, then twin turbos (off Merkur XR4Tis) and finally a Paxton ball-drive supercharger (FleaBay).
The nitrous made the most power easiest, no doubt but, refilling the bottle and watching its heat and pressure got old. The turbos made insane power but the underhood heat was ridonkulous and, fuel side tuning on a speed density 5.0 was difficult. The antique ball-drive blower I rebuilt, replacing a couple races and balls and that thing soldiered through 5 seasons of drag racing and street driving, no complaints. It made for the nicest driving feel, as well.
Not fancy, like some of the suggestions here but, my whole ideology was build it cheap, make it fast, beat high-dollar cars at the strip and that old POS did that pretty consistently.
I'd never do that with this car. This one, I'm going to start with traction aids (relocation brackets) and then hit the electronic side first, as the car makes pretty good power as is. I'd like better driveability, though, the factory tune isn't how I'd set it up, personally.