Fack , I had 200,000 on my last pushrod 5.0 when I added a supercharger and, it had already been variously twin turnoff and had nitrous
shot through it for years at the track. I sold the car running and driving as well as ever and nothing ever broke but clutches, tires and a few sets of squeezed head gaskets. So, I'd say no.
A bad tune can kill any engine though. Make sure you work with reputable vendors and tuners.
2014 Premium GT, SGM, Brembo, Auto, Tech, Comfort, etc. GT500s, Steeda UCA, VMP auto N/A tune. 100 shot nitrous on BBR tune. Best e/t 11.38 at 120.85
2012 Premium GT, Candy Red, Brembo package, 3.73, MT82, Comfort, Tech, et al. Procal tune, Roush UCA, UMI poly LCA, GT500s, Steeda red bracket, Hoosier 28x10x16 bias drags. Best e/t 11.91 at 115.23 RIP