If you don't know what Spore is, its a new game comming out by Will Wright, the developer of SimCity and the Sims. I believe its coming out for all consoles and PC. Basically Spore is going to be evolution of a single celled organism all the way to a civilization capable of interstellar travel who can terraform other planets and even destroying entire planets like the Death Star.
If you are really intrigued I suggest watching this 35 minute presentation on the game. It's long, but if you have time and can apreciate a work of art of a game check this out. Its disgusting.
Spore Gameplay Video - Google Video
If you rather watch just a short trailer of it check out...
YouTube - Spore - E3 2006 B-Roll
But its definitely not as good and doesn't give you a good idea of what the game is about.
I'm pretty excited about this game.. I personally can't wait to get my hands on it. The world you live in depends on your actions and stuff.. the other species and civilizations in your galaxy are going to be downloaded from other players as well as your species and civilization being uploaded. You can even create a sea species or a flying species I believe. Depending on how your creature evolved will create its own personality which could be different than other species on your planet as well as other galaxies. Even the appearance of your civilization with its housing, vehicles, UFOs and other stuff also depends on your species. It's going to be one hell of a program.